Original Investigation
Adjunctive Antipsychotics in Major Depressive Disorder. A Systematic Review and Network Meta-Analysis
Roger S. McIntyre, MD1,2,3; Stephen M. Stahl, MD, PhD4; Sung Ryul Shim, MPH, PhD5, et al. JAMA Psychiatry. Published Online: May 6, 2026. doi: 10.1001/jamapsychiatry.2026.0658
Key Points
Question How do...
Schizophrenia: Which of Seven Antipsychotics Wins on Acute Efficacy and Safety?
Published on May 1, 2026 Certification expiration date: May 1, 2029 DOI: 10.64239/PI-QT8603
Oliver Freudenreich, M.D., F.A.C.L.P.
Co-director of the MGH Psychosis Clinical and Research Program & Professor of Clinical Psychiatry – Massachusetts General Hospital – Harvard Medical...
Highlights
There is a long delay in initiating clozapine during routine clinical practice.
The delay may be an independent predictor of symptomatic outcome.
Clinicians should reduce the delay in initiating clozapine to less than 3 years.
Abstract
Previous studies have suggested that a delay in initiating clozapine is one of the predictors of outcomes in...
